Biotic Detox Support High-Potency, Probiotic Adjunct for Detoxification
with InTacticTM acid-stable technology
DESCRIPTION
Biotic Detox Support probiotic supplement supplies large numbers of beneficial bacteria that support the body's natural detoxification process and help maintain a healthy balance of friendly intestinal flora during detoxification protocols such as antibiotic therapy, antifungal /anti-microbial medications, or heavy metal chelating agents. A total probiotic count of 50+ billion CFUs of a combination of Lactobacillus rhamnosus, Lactobacillus casei,and Bifidobacterium bifidumis provided in each capsule. Certified American Type Culture Collection (ATCC) probiotic strains of human origin are supplied in a base of inulin and encapsulated in two-piece Kosher-certified vegetarian capsules. Klaire's InTactic™ acid-stable delivery technology, a proprietary hypoallergenic polysaccharide complex, is included to protect microorganism potency during transit through the acidic gastric environment. Biotic Detox Support is a hypoallergenic product free of common allergens, including dairy products, casein, gluten, corn, soy, egg, sugar, yeast, and maltodextrin. No artificial additives, colorings, flavoring, preservatives, or salicylates are used. A small amount of L-leucine, a naturally-occurring amino acid, is used as an encapsulation aid.
OVERVIEW
Detoxification, defined as the reduction or removal of the toxic qualities of a substance, is an important part of the body's natural defense process. Exposure to toxins such as heavy metals and other environmental pollutants, ingested chemicals including alcohol and drugs, infectious agents, and metabolic by-products occurs throughout an individual's lifespan. Disease or even death can result when the burden of accumulated toxins outweighs the body's ability to safely eliminate them. A variety of treatment regimens aimed at enhancing the body's detoxification mechanisms are available to assist elimination or neutralization of toxic burdens. These include heavy metal chelating agents to reduce levels of mercury, lead, and other toxic elements; broad-spectrum antibiotics to eliminate bacterial pathogens; prescription anti-fungal or anti-parasitic agents; and nutritional compounds that help support intestinal and hepatic detoxification pathways. Some detoxification protocols, however, generate additional toxins or metabolic by-products that can further compromise health if they also are not efficiently cleared from the system. The normal, healthy balance of intestinal flora can be disturbed by some pharmaceutical agents or compromised by uncleared toxins, resulting in Intestinal dysbiosis. Increasing scientific evidence indicates that oral administration of probiotic organisms can support the body's natural detoxification process in several ways. Probiotic supplements counterbalance the adverse effects on friendly flora from certain medications by replacing beneficial bacteria and thereby avoiding dysbiosis. They also assist detoxification processes by sequestering metals and other toxins, thereby inhibiting their uptake and facilitating safe elimination through the intestinal tract. Oral administration of large populations of live, health-promoting lactic acid bacteria, referred to as probiotic bacteriotherapy, can augment detoxification protocols as follows:
Role of Probiotics in Detoxification Processes
Probiotics may beneficially modulate intestinal detoxification functions that naturally contribute to a protective effect on the colon. Gut flora, especially following the ingestion of resistant starch, induces the chemo preventive enzyme glutathione transferase in the colon of the rat. In humans, the ingestion of probiotics leads to the excretion of urine with low concentrations of components that are genotoxic in human colon cells and high concentrations of components that induce oxidized DNA bases. When ingested with prebiotics, probiotics facilitate the production of high concentrations of short-chain fatty acids. Butyrate, an important short-chain fatty acid that serves as fuel for colon cells, may inhibit the genotoxic activity of nitrosamides and hydrogen peroxide in human colon cells. Direct binding of heterocyclic aromaticamines (HAs) to the cell walls of certain bacterial strains contained in fermented foods has been observed to take place under physiologically relevant conditions. These observations suggest that intestinal bacteria may be useful for dietary detoxification and protection strategies to facilitate removal of selected mutagens.
Role of Probiotics in Anti-Microbial Protocols
Administration of pharmaceutical drugs for treatment of bacterial, viral, yeast, or parasitic infections not only results in death of pathogenic organisms but also liberates a number of toxins, cellular debris, and by-products into the intestinal tract following death of the cell. The body's defenses are generally primed to respond to such an insult. However, use of these agents in individuals with compromised detoxification processes or gastrointestinal dysfunction may set the stage for adverse consequences that can manifest as a systemic (Herxheimer) reaction. The Herxheimer response (also described as a "die-off" reaction) can occur when live pathogens are killed and cellular toxins and by-products are released from lysed cells and transported into the circulation to be cleared from the body. Once absorbed into the bloodstream, these substances can cause adverse reactions that manifest as fatigue, skin hives, joint pain, or flu-like symptoms. Use of high potencies of probiotics can play a supportive role in clearing the released toxins and by-products from the intestinal tract before they have a chance to be absorbed, thereby lessening the likelihood of adverse responses.
Role of Probiotics in Metal Chelation Protocols
Use of heavy metal chelating agents such ethylenediaminetetraacetic acid (EDTA) and dimercaptosuccinicacid (DMPA) act to mobilize tissue stores of toxic metals and facilitate their removal from the body. This can result in production of toxic debris and other by-products of chelation that are passed into the intestinallumen. Additionally, not all of the chelated metal will remain bound to the chelating agent during passage through the body. Once present in the intestinal tract, these compounds and liberated metals have the potential to adversely affect enterocytes and gut-associated lymphoid tissue (GALT) or be reabsorbed back into the bloodstream. These toxins and by-products may also adversely affect the live friendly intestinal flora, including Lactobacilliand Bifidobacteriumstrains, and/or serve as a food source for yeast and bacterial organisms. An exacerbation or onset of intestinal dysbiosis may result. Administration of live probiotics during chelation protocols can help maintain a healthy balance of friendly flora that help keep the population of undesirable organsims in check. Probiotics serve another useful role in the handling and clearance of metal compounds, as they are capable of sequestering mercury as it passes through the intestinal tract, thereby reducing its absorption. Probiotics also reduce highly toxic organic methylmercury into less toxic elemental mercury. Following internalization and detoxification of organic mercury within the probiotic organisms, elemental mercury escapes from the bacteria and is released back into the intestine. Here it may continue towards excretion, reabsorption, or reuptake by either pathogenic or probiotic bacteria. In the presence of chloride and strong acid, the elemental mercury may be converted into mercuric chloride that can then be taken up by either pathogenic or probiotic bacteria. Interestingly, it is known that both pathogenic and beneficial enteric bacteria, as well as yeasts, are all capable of producing methylmercury from mercuric chloride. However, pathogenic organisms such as E. colimake this conversion at a much faster rate, yielding 2 to 7.5 times more methylmercury in the same period of time. Yeast were shown to make the conversion more than 4 times faster than probiotic organisms. Consequently, when beneficial bacteria predominate, their ability to sequester and move mercury towards excretion coupled with a much slower reconversion rate has the net effect of eliminating mercury in a less toxic form and reducing the opportunity for mercury to adversely affect GI tissues or be reabsorbed.
PROBIOTIC STRAINS
Biotic Detox Support supplies high concentrations of three selected probiotic strains noted for protective activities as follows:
Lactobacilllus rhamnosus
As a primary resident of the small intestine, Lactobacilllus rhamnosusadheres to and colonizes the mucosal membrane where it exerts important health-promoting functions. It enhances cellular immunity by increasing immunoglobulin IgA and stimulating phagocytosis. It also reduces intestinal inflammation and mucosal barrier permeability in infants with allergic dermatitis. This strain functions by competitive exclusion ofpathogenic organisms including E. coli, Listeria, Clostridia, Shigella and Salmonella, etc. L. rhamnosus can also assist the immune system in resisting pathogenic organisms such as bacteria and yeast that promoteintestinal inflammation and damage membranes.
Lactobacillus casei
L.caseiis a common lactic acid bacteria found in the mouth and membrane of the small intestine where it shares many of the same immune-modulating effects exerted by other lactobacilli family members. It helps intestinal cells respond appropriately when the immune system is challenged by enhancing the number of IgA-producing cells in the mucosal membrane. T-lymphocytes, which have an important role in the mucosal immune response, are also increased by higher populations of L. casei.The cell wall of the L. casei strain contains teichoic acid which participates in adherence of L. caseito epithelial tissue where it inhibits attachment of pathogenic organisms. A protective effect against DNA damage in cells in the GI tract has been observed when high concentrations of L. caseiare administered prior to carcinogen exposure in rats.
Bifidobacterium bifidum
B. bifidum(also recognized as B. lactis)is primarily found in the digestive system of adults and children, but is especially important to and prevalent in high numbers in breastfed infants. B. bifidumis a common resident in the mucus membranes lining the distal part of the small intestine, the large intestine, and the vaginal tract, where it attaches to the luminal walls, crowding out yeast (Candida albicans)and pathogens(Clostridium, Salmonella, etc.) by competing for nutrients. B. bifidumalso produces acetic and lactic acid, which lowers the pH (increases the acidity) of the intestine, thus inhibiting growth of undesirable bacteria. A role in detoxification has been demonstrated with use of this bifidobacterium strain. B. bifidum administered to 20 patients with liver disease produced a significant decrease in blood ammonia, free serum phenol, and free amino nitrogen.
INULIN OLIGOSACCHARIDE BASE
Inulin is a natural, non-digestible oligosaccharide derived from the chicory root vegetable. Recognized for its ability to function as a "pre-biotic", inulin is used a fuel source to stimulate or increase the growth of beneficial bacteria (Bifidobacteria)which have a role in reducing the growth of pathogens in the intestinal tract. This naturally-derived base ingredient is generally well-tolerated by the highly sensitive patient. It isused in place of corn- or wheat-derived maltodextrin, commonly use as a base ingredient in the majority of probiotic supplements.
INTACTICTM ACID-STABLE DELIVERY SYSTEM
Probiotic viability of Biotic Detox Support is protected by InTactic™ acid stable technology. InTactic™ is highly purified polysaccharide material of marine origin that forms a gel-like matrix that surrounds and protects the probiotic bacteria from destruction by gastric acid. This allows the friendly flora to survive exposure to stomach acids and be delivered alive into the small intestines where they are released intact to exert their health promoting function.
INDICATIONS
Biotic Detox Support Support is recommended whenever support for intestinal detoxification mechanisms is indicated. It may be especially useful in conjunction with agents that may adversely affect the population of beneficial intestinal flora, including during and following use of broad-spectrum antibiotics, anti-microbial or anti-parasitic medications, anti-fungals/anti-candida drugs, or heavy metal chelating compounds. Biotic Detox Support may also be used whenever an intensive approach toreplacement with large quantities of probiotic Lactobacillus and Bifidobacteriumis desired.
FORMULA
Supplement Facts Serving Size 1 Capsule Amount Per Serving Probiotic Blend210 mg*Lactobacillus rhamnosus20+ billion CFUs*Bifidobacterium bifidum15+ billion CFUs*Lactobacillus casei15+ billion CFUs**Daily Value not established. Other Ingredients: Inulin base derived from chicory root, proprietary polysaccharide complex, Vcaps™ vegetarian capsule, water, cellulose, and L-leucine.
SUGGESTED USE
One capsule daily or as directed by physician. Capsules may be pulled apart and contents taken separately if desired.
ADVERSE REACTIONS
None reported.
CONTRAINDICATIONS
Individuals sensitive to chicory root (inulin source) may wish to avoid use of this product.
DRUG INTERACTIONS
None reported.
HOW SUPPLIED
60 VcapsTM vegetarian capsules per blue glass bottle. Packaged 12 bottles per case.
STORAGE
Probiotics are sensitive to warm temperature, therefore, this product is shipped with ice packs to protect from temperature extremes during transit. Keep refrigerated and tightly closed to maintain product potency.
REFERENCES
Bernet MF, Brassart D, Neeser JR, and Servin AL. Adhesion of human bifidobacterial strains to cultured human intestinal epithelial cells and inhibition of enteropathogen-cell interactions. Appl Environ Microbiol1993; 59: 4121-4128. Dunne C, O'Mahony L, Murphy L, Thornton G, et al. In vitro selection criteria for probiotic bacteria of human origin: correlation with in vivo findings. American Journal of Clinical NutritionVol. 73, No. 2, 386S-392s, February 2001.Elmer GW, CM Surawicz, LV McFarland. Biotherapeutic agents. A neglected modality for the treatment and prevention of selected intestinal and vaginal infections. JAMA(1996) 276:29-30.Gorbach S. Lactic acid bacteria and human health. Ann Of Med1990; 22: 37-41.Knasmuller S, Steinkellner H, Hirschl AM, Rabot S, Nobis EC, Kassie F. Impact of bacteria in dairy products and of the intestinalmicroflora on the genotoxic and carcinogenic effects of heterocyclic aromatic amines. Mutat Res2001 Sep 1;480-481:129-38.Lidbeck A, Nord CE, Gustafsson JA, and Rafter J, Lactobacilli. anticarcinogenic activities and human intestinal microflora.
Eur J Cancer Prev1992; 1: 341-353.Lin MY and CL Yen. Antioxidative ability of lactic acid bacteria. JAgric Food Chem(1999) 47:1460-1466. Mital BK and GargSK. Anticarcinogenic, hypocholesterolemic, and antagonistic activities of Lactobacillus acidophilus.
Critical Rev Microbiol1995; 21(3): 174-214.Naidu AS, WR Bidlack, RA Clemens. Probiotic spectra of lactic acid bacteria (LAB). CRC Critical Rev Fd Sci Nutr2000; 39(1):13-126.Rowland IR, Grasso P, Davies MJ. The methylation of mercuric chloride by human intestinal bacteria. Experientia1975 Sep15;31(9):1064-5.Saikali J, Picard C, Freitas M, Holt P. Fermented milks, probiotic cultures, and colon cancer. Nutr Cancer2004;49(1):14-24.Turbic A, Ahokas JT, Haskard CA. Selective in vitro binding of dietary mutagens, individually or in combination, by lactic acid bacteria. Food Addit Contam2002 Feb;19(2):144-52.Wollowski I, Rechkemmer G, Pool-Zobel BL. Protective role of probiotics and prebiotics in colon cancer. Am J Clin Nutr2001Feb;73(2 Suppl):451S-455S.
Statements made herein have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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